Sam and Dean Head to Chicago in Supernatural’s “Bloodlines”

Sam and Dean are headed to Chicago in Supernatural’s much anticipated “Bloodlines” episode this April 29.

The episode will serve as a backdoor pilot for a new series currently in development called Supernatural: Bloodlines (formerly Tribes) which if picked up, will run with its parent show next season.

The “Bloodlines” episode introduces characters from the new series and sees Sam (Jared Padalecki) and Dean (Jensen Ackles) investigating a case in Chicago, where they discover that various mafia-esque monster families are, unknown to humans, running the underbelly of Chicago.

One is a family of shapeshifters run by Margo Lassiter (guest stars Danielle Savre), whose leadership is thrown into question when her brother David (guest star Nathaniel Buzolic) returns home.

The other reigning family in town is made up of werewolves, lead by Julian Duval (guest star Sean Faris).

While in Chicago, Sam and Dean meet Ennis (guest star Lucien Laviscount), a man with a personal vendetta against the monsters.

The Winchesters warn Ennis about heading into the hunter lifestyle, but Ennis refuses to listen and starts down a dangerous path.

Robert Singer directed the episode written by Andrew Dabb.